Back to News

Dec 05, 2010

New Clinical Data Evaluating ISTODAX(R) in Pivotal Open-Label Phase II Study for Patients with Peripheral T-Cell Lymphoma (PTCL)

BOUDRY, Switzerland, Dec 05, 2010 (BUSINESS WIRE) -- Celgene International Sаrl (Nasdaq:CELG) today announced that data from a pivotal Phase II, multicenter, international, open-label study of romidepsin (ISTODAX(R)) in progressive or relapsed PTCL following prior systemic therapy were presented at the 52nd American Society of Hematology Annual Meeting.

In the study, patients with histopathologically confirmed PTCL who failed or were refractory to prior systemic therapy received 14 mg/m2 of ISTODAX as a four-hour infusion on days 1, 8 and 15 of a 28-day cycle for up to six cycles. Treatment could be extended for response or stable disease.

Of 130 patients with histopathologically confirmed PTCL in the study, the overall response rate was 26% (34/130), as assessed by an Independent Review Committee (IRC) using the International Workshop Criteria. Thirteen percent (17/130) of patients achieved a complete response - the primary endpoint of the study - and another 13% (17/130) achieved a partial response. The median duration of response for all patients who responded was 12 months (range 1-801+ days). The median duration of response for patients who achieved a complete response has not been reached (median duration of follow-up: 8.2 months), and 82% (14/17) of patients with a complete response had not progressed as of the data cut-off for the IRC evaluation (March 31, 2010).

Toxicities associated with ISTODAX(R) in the study were as follows: 96.2% (126/131) of patients evaluable for safety experienced at least one treatment-emergent adverse event, with the most common grade 3 or higher adverse events reported as thrombocytopenia (24% 31/131), neutropenia (20% 26/131), infections (17% 22/131) and anaemia (10% 13/131).

Romidepsin (ISTODAX) is not approved as a treatment in progressive or relapsed PTCL.

About ISTODAX

ISTODAX(R) (romidepsin) is a member of a new class of cancer drugs known as histone deacetylase (HDAC) inhibitors. HDACs catalyze the removal of acetyl groups from acetylated lysine residues in histones, resulting in the modulation of gene expression. HDACs also deacetylate non-histone proteins, such as transcription factors. HDAC inhibitors can be divided into four main classes: cyclic tetrapeptides (I), short-chain fatty acids (II), hydroxamic acids (III), and benzamides (IV). The cyclic peptide structure of ISTODAX is novel among the cyclic tetrapeptides. In vitro, ISTODAX causes the accumulation of acetylated histones, and induces cell cycle arrest and apoptosis of some cancer cell lines. For full prescribing information, visit www.ISTODAX.com.

ISTODAX is approved in the United States for the treatment of cutaneous T-cell lymphoma (CTCL) in patients who have received at least one prior systemic therapy.

Important Safety Information

ISTODAX is indicated for treatment of cutaneous T-cell lymphoma (CTCL) in patients who have received at least one prior systemic therapy.

Warnings and Precautions

Due to the risk of QT prolongation, potassium and magnesium should be within the normal range before administration of ISTODAX.

Treatment with ISTODAX can cause thrombocytopenia, leukopenia (neutropenia and lymphopenia), and anaemia; therefore, these haematological parameters should be monitored during treatment with ISTODAX, and the dose should be modified, as necessary.

Several treatment-emergent morphological changes in ECGs including T-wave and ST-segment changes have been reported in clinical studies. The clinical significance of these changes is unknown. In patients with congenital long QT syndrome, patients with a history of significant cardiovascular disease, and patients taking anti-arrhythmic medicines or medicinal products that lead to significant QT prolongation, appropriate cardiovascular monitoring precautions, such as the monitoring of electrolytes and ECGs should be considered.

Based on its mechanism of action, ISTODAX may cause fetal harm. Woman should avoid becoming pregnant while being treated with ISTODAX and pregnant women should be advised of the potential harm to the foetus.

ISTODAX binds to oestrogen receptors. Women of childbearing potential should be advised that ISTODAX may reduce the effectiveness of oestrogen-containing contraceptives.

Adverse Reactions

Safety data was available and evaluated in 185 patients with CTCL in two clinical trials. Adverse reactions are presented separately for each study due to methodological differences between the studies. The most common reported adverse reactions in Study 1 were nausea (56%), fatigue (53%), infections (46%), vomiting (34%), and anorexia (23%) and in Study 2 were nausea (86%), fatigue (77%), anaemia (72%), thrombocytopenia (65%), ECG T-wave changes (63%), neutropenia (57%), and lymphopenia (57%). Most of the adverse reactions were reported to be mild or moderate in severity. Most deaths in the studies were due to disease progression. Discontinuation due to an adverse event occurred in 21% of patients in Study 1 and 11% in Study 2. Serious adverse reactions reported in > 2% of patients in Study 1 were infection, sepsis, and pyrexia. In Study 2, serious adverse reactions in > 2% of patients were infection, supraventricular arrhythmia, neutropenia, fatigue, oedema, central line infection, ventricular arrhythmia, nausea, pyrexia, leukopenia, and thrombocytopenia.

Drug Interactions

Prothrombin time (PT) and International Normalized Ratio (INR) should be carefully monitored in patients concurrently administered ISTODAX and Coumadin derivatives.

Co-administration of strong CYP3A4 inhibitors may increase concentrations of ISTODAX and should be avoided.

Co-administration of potent CYP3A4 inducers may decrease concentrations of ISTODAX and should be avoided.

Caution should be exercised if ISTODAX is administered with drugs that inhibit P-glycoprotein.

Use in Specific Patient Populations

Patients with moderate and severe hepatic impairment or end-stage renal disease should be treated with caution.

About PTCL

Peripheral T-cell lymphoma is a term that encompasses a number of different malignancies of T-cell origin that account for about 10-15% of all cases of non-Hodgkin's lymphoma. PTCL can occur at any age from young adulthood to old age and is slightly more common in men than in women. It is a particularly aggressive form of lymphoma with a short median duration of life expectancy (approximately two years) from diagnosis.

About Celgene International Sаrl

Celgene International Sаrl, located in Boudry, in the Canton of Neuchвtel, Switzerland, is a wholly owned subsidiary and international headquarters of Celgene Corporation. Celgene Corporation, headquartered in Summit, New Jersey, is an integrated global pharmaceutical company engaged primarily in the discovery, development and commercialization of innovative therapies for the treatment of cancer and inflammatory diseases through gene and protein regulation. For more information, please visit the Company's website atwww.celgene.com.

This release contains certain forward-looking statements which involve known and unknown risks, delays, uncertainties and other factors not under the Company's control, which may cause actual results, performance or achievements of the Company to be materially different from the results, performance or other expectations implied by these forward-looking statements. These factors include results of current or pending research and development activities, actions by the FDA and other regulatory authorities, and those factors detailed in the Company's filings with the Securities and Exchange Commission such as 10K, 10Q and 8K reports.

SOURCE: Celgene International Sаrl

Celgene International Sаrl
Kevin Loth, +41 32 729 86 21
Director of External Relations

All news about Gloucester Pharmaceuticals

More News

May 18, 2017

Aileron Announces Oral Presentation at ASCO on ALRN-6924 Targeting p53

Read more

May 16, 2017

Braeburn Keeps Up with Competitors with LongActing Risperidone for Schizophrenia

Read more

May 10, 2017

Otic Pharma Completes Merger with Tokai Pharmaceuticals

Read more

May 02, 2017

Braeburn and Camurus Announce Positive Top-line Results

Read more

May 01, 2017

National Opioid Addiction Treatment Leader Launches Center in Hartford

Read more

May 01, 2017

National Opioid Addiction Treatment Leader Launches Center in Arlington

Read more

Apr 26, 2017

Braeburn Achieves Primary Endpoint in Pivotal Phase 2/3 Study of BB0817

Read more

Apr 24, 2017

New addiction treatment center adds to fight

Read more

Apr 21, 2017

New Addiction Treatment Facility To Open In Hartford

Read more

Apr 20, 2017

CURE FORWARD

Read more

Apr 17, 2017

National Opioid Addiction Treatment Leader Launches 1st of Three Phoenix Centers

Read more

Apr 11, 2017

CleanSlate Centers' CMO Begins Term as President of ASAM

Read more

Apr 04, 2017

National Opioid Addiction Treatment Leader Launches Center in Lawrence

Read more

Mar 20, 2017

Syntimmune Announces Breakthrough Results of FcRn Inhibition Published in PNAS

Read more

Mar 09, 2017

Fight Colorectal Cancer Partners With Cure Forward

Read more

Feb 20, 2017

CleanSlate Centers' Officials Join District Attorney's Addiction Task Force

Read more

Feb 20, 2017

Indiana Medicaid Members Gain Access to Leading Addiction Treatment

Read more

Feb 13, 2017

Fast Company Honors Braeburn as a Top Ten Most Innovative Company in Biotech

Read more

Jan 13, 2017

Braeburn Pharmaceuticals’ Probuphine® Implant Receives J-Code

Read more

Jan 04, 2017

Opioid Addiction Treatment Leader CleanSlate Launches Center in Fort Wayne

Read more

Dec 22, 2016

Tokai Pharmaceuticals and Otic Pharma Enter into Share Purchase Agreement

Read more

Dec 19, 2016

CleanSlate Centers Adds Executive to East Division Leadership

Read more

Dec 12, 2016

National Opioid Addiction Treatment Leader CleanSlate Launches Center in Elkhart

Read more

Nov 21, 2016

Braeburn and CEO Behshad Sheldon Win Stevie Awards

Read more

Nov 17, 2016

Syntimmune Announces Appointment of David De Graaf, Ph.D., as CEO

Read more

Nov 14, 2016

Braeburn Pharmaceuticals and Camurus Announce Positive Top-line Phase 3 Results

Read more

Oct 31, 2016

Opioid Addiction Treatment Leader CleanSlate Launches Center in East Boston

Read more

Oct 27, 2016

​ Probuphine® Wins Popular Science’s “Best of What’s New” Award

Read more

Oct 24, 2016

Braeburn Pharmaceuticals and Camurus Expand Collaboration and License Agreement

Read more

Oct 21, 2016

Braeburn and Camurus announce the presentation of new data

Read more

Oct 04, 2016

OPTUM, CLEANSLATE TO EXPAND ACCESS TO OPIOID ADDICTION TREATMENT FOR MEMBERS

Read more

Oct 03, 2016

Opioid Addiction Treatment Leader CleanSlate Launches Center in Merrillville

Read more

Sep 30, 2016

Braeburn and Camurus Enroll First Patients in a Phase 3 Efficacy Trial

Read more

Sep 22, 2016

Cure Forward Names Consumer Healthcare and IT Veteran Frank Ingari as CEO

Read more

Sep 08, 2016

Tokai Pharmaceuticals Announces Review of Strategic Alternatives

Read more

Sep 06, 2016

ROX Medical Raises $40M Financing

Read more

Aug 30, 2016

Cure Forward Stresses Patient Data Access as Trial Matching Service Matures

Read more

Aug 27, 2016

HeartWare Receives FDA Approval To Enroll Supplemental Patient Cohort In Trial

Read more

Aug 23, 2016

Medtronic Completes Acquisition of HeartWare International

Read more

Aug 15, 2016

National Opioid Addiction Treatment Leader CleanSlate Opens Center in Anderson

Read more

Aug 02, 2016

Cure Forward Selects Personal Genome Diagnostics

Read more

Jul 29, 2016

VytronUS, Inc. Raises $49 Million in Series C Financing

Read more

Jul 29, 2016

Apple Tree Bankrolls Johnson & Johnson Spinout Tusker Medical

Read more

Jul 29, 2016

Tokai Pharmaceuticals Announces Reduction in Force

Read more

Jul 20, 2016

Anthony Belott joins CleanSlate Centers as Chief Development Officer

Read more

Jul 19, 2016

Braeburn Pharmaceuticals Announces Probuphine Data Published

Read more

Jul 06, 2016

High-Tech Healthcare Helps Eliminate Unnecessary Hospital Visits

Read more

Jun 28, 2016

Cure Forward Announces First Trial Recruitment Collaboration

Read more

Jun 27, 2016

Medtronic to Expand Portfolio with Acquisition of HeartWare International

Read more

Jun 26, 2016

Tokai Pharmaceuticals Announces Clinical Update

Read more

Jun 13, 2016

CleanSlate Centers names Gregory C. Marotta President & CEO

Read more

Jun 08, 2016

CleanSlate, a Massachusetts based addiction treatment center, expands nationally

Read more

Jun 02, 2016

Tokai Pharmaceuticals to Participate in Upcoming Investor Conferences

Read more

May 26, 2016

FDA approves first buprenorphine implant for treatment of opioid dependence

Read more

May 18, 2016

Tokai Announces Publication of 3 Abstracts on Galeterone at 2016 ASCO Annual Mtg

Read more

May 10, 2016

Tokai Pharmaceuticals Reports First Quarter 2016 Financial Results

Read more

May 05, 2016

Tokai to Present at Bank of America Merrill Lynch 2016 Health Care Conference

Read more

Apr 26, 2016

Tokai Announces Oral Presentation on Galeterone at the 2016 AUA Annual Meeting

Read more

Apr 20, 2016

Dermatology Services Company QualDerm Unveils $31.8M Growth Investment

Read more

Apr 13, 2016

Tokai Announces Presentations on Galeterone at the AACR Annual Meeting 2016

Read more

Apr 06, 2016

Tokai Pharmaceuticals to Present at 15th Annual Needham Healthcare Conference

Read more

Mar 30, 2016

Tokai Announces Dosing of First Patient in Phase 2 Expansion Study of Galeterone

Read more

Mar 22, 2016

Syntimmune Secures Second Tranche of $26 Million Series A Financing

Read more

Mar 21, 2016

Tokai Strengthens Development Team Through the Addition of Kelly Lindert, M.D.

Read more

Mar 10, 2016

Tokai Pharmaceuticals Reports Full Year 2015 Financial Results

Read more

Feb 22, 2016

Braeburn and Camurus Announce Initiation of a Phase 2 Study

Read more

Feb 17, 2016

Corvidia Therapeutics Raises $26M in a Series A Financing

Read more

Feb 01, 2016

Braeburn Pharmaceuticals and Knight Therapeutics Announce

Read more

Jan 14, 2016

Titan Pharmaceuticals and Braeburn Pharmaceuticals Announce FDA Advisory

Read more

Jan 08, 2016

Tokai Announces Presentation New Data Highlighting Unique Galeterone Mechanism

Read more

Jan 07, 2016

Tokai Announces Update on ARMOR3-SV and Expanded Galeterone Clinical Dev Program

Read more

Dec 15, 2015

Braeburn Pharmaceuticals and Camurus Announces Start of Phase 3 Trial

Read more

Dec 09, 2015

Titan Pharmaceuticals and Braeburn Pharmaceuticals Announce Date of FDA Review

Read more

Nov 10, 2015

Tokai Pharmaceuticals Reports Third Quarter 2015 Financial Results

Read more

Nov 09, 2015

CleanSlate Launches STAT Campaign for Physician Awareness of PA Opioid Epidemic

Read more

Nov 04, 2015

FDA Grants Fast Track Designation for Development of CAM2038

Read more

Oct 01, 2015

Pharmatech and Cure Forward to Accelerate Oncology Clinical Trial Enrollment

Read more

Sep 28, 2015

FDA Accepts Braeburn’s Resubmission of Probuphine NDA for Review

Read more

Sep 22, 2015

Cure Forward Launches Precision Medicine Engagement Platform for Cancer Patients

Read more

Sep 20, 2015

Paul L. Chabot Joins CleanSlate Centers as the New CIO

Read more

Sep 17, 2015

Braeburn Pharmaceuticals Commends HHS Secretary Burwell

Read more

Sep 14, 2015

Patrick J. Murphy Joins CleanSlate Centers as the New Chief Financial Officer

Read more

Sep 04, 2015

Geisinger Health Plan Establishes Relationship with CleanSlate Centers

Read more

Aug 12, 2015

Tokai Pharmaceuticals Reports Second Quarter 2015 Results

Read more

Jul 30, 2015

Abbott to Broaden Foundation in Structural Heart Therapies

Read more

Jun 24, 2015

Tokai Announces Initiation of Phase 3 ARMOR3-SV Trial of Galeterone

Read more

Jun 23, 2015

Gregory C. Marotta Joins CleanSlate Centers as the New Chief Operating Officer

Read more

Jun 18, 2015

Cure Forward Receives $15 Million in Series A Financing

Read more

Jun 08, 2015

Braeburn Reports Positive Results From Phase 3 Study

Read more

Jun 01, 2015

Patrick J Kennedy Accepts Seat on Board of Directors at CleanSlate Centers

Read more

May 12, 2015

Tokai Pharmaceuticals Reports First Quarter 2015 Financial Results

Read more

Apr 14, 2015

Tendyne Announces First Patient Enrolled in US Trial

Read more

Apr 09, 2015

Tendyne Raises $25 Million in Series C

Read more

Apr 06, 2015

VytronUS, Inc. Attracts Industry Veteran John Pavlidis as New President and CEO

Read more

Mar 12, 2015

Tokai Reports Fourth Quarter and Full Year 2014 Financial Results

Read more

Feb 12, 2015

Aileron Therapeutics Initiates Phase 1 Cancer Study of ALRN-6924

Read more

Dec 15, 2014

The Tendyne TMVI system was successfully implanted in the first patient

Read more

Dec 02, 2014

Tendyne Announces Successful First Human Implants of TMVI

Read more

Nov 19, 2014

Tokai Pharmaceuticals Presents Updated Interim Galeterone ARMOR2 Data

Read more

Nov 10, 2014

Tokai Pharmaceuticals Reports Third Quarter 2014 Financial Results

Read more

Oct 29, 2014

​VytronUS, Inc. Raises $31.6 Million in Series B

Read more

Oct 29, 2014

Aileron Therapeutics Secures $33 Million in Series E

Read more

Sep 24, 2014

Braeburn Pharmaceuticals’ Probuphine® Study Hits Enrollment Milestone

Read more

Sep 23, 2014

Tokai Pharmaceuticals Announces Closing of Initial Public Offering

Read more

Jun 02, 2014

Tokai Pharmaceuticals Presents New Clinical Data for Galeterone

Read more

May 16, 2014

Updated Phase 2 Clinical Data on Tokai Pharmaceuticals’ Galeterone

Read more

Mar 07, 2014

Titan Announces Agreement in Principle for Probuphine Clinical Study

Read more

Feb 03, 2014

Tokai's Reformulated Galeterone Demonstrates Robust PSA Reductions

Read more

Jan 13, 2014

New Phase 2 Clinical Data on Tokai Pharmaceuticals’ Galeterone

Read more

Nov 18, 2013

Aileron Therapeutics has secured $30 million in Series E equity financing

Read more

Nov 15, 2013

Titan Pharmaceuticals Announces $5 Million Equity Investment

Read more

Sep 26, 2013

Frank E. Young, Former FDA Commissioner, Joins Braeburn Pharmaceuticals as EVP

Read more

Aug 15, 2013

Aileron Therapeutics Publishes Data

Read more

Aug 13, 2013

Titan Announces Publication of Phase 3 Probuphine Data in Additiction

Read more

Aug 09, 2013

HeartWare Presentation At The Canaccord Genuity 2013 Annual Growth Conference

Read more

Aug 08, 2013

HeartWare International Reports $50.8 Million In Second Quarter 2013 Revenue

Read more

Jun 17, 2013

HeartWare Receives Conditional Approval From FDA

Read more

May 15, 2013

Tokai Pharmaceuticals Announces $35.5 Million Series E Financing

Read more

May 07, 2013

Aileron Successfully Completes First-Ever Stapled Peptide Clinical Trial

Read more

Apr 29, 2013

HeartWare International Reports $49.2 Million In First Quarter 2013 Revenue

Read more

Apr 10, 2013

Aileron Therapeutics Presents New Preclinical Data on Stapled Peptide

Read more

Apr 04, 2013

Tokai Announces Presentation of Galeterone Mechanism of Action Data

Read more

Mar 28, 2013

Tokai Pharmaceuticals Announces Appointment of Jodie Morrison as CEO

Read more

Mar 22, 2013

Titan Announces FDA Advisory Committee Recommends Approval of Probuphine®

Read more

Mar 14, 2013

Titan announces date of FDA Advisory Committee Review of PROBUPHINE®

Read more

Mar 12, 2013

HeartWare Announces Pricing of Public Offering of Common Stock

Read more

Mar 04, 2013

Tokai to Present Data on Galeterone in Advanced Prostate Cancer

Read more

Jan 14, 2013

Aileron Secures $12 Million for First-Ever Stapled Peptide Clinical Trial

Read more

Jan 07, 2013

HeartWare International Announces Preliminary Fourth Quarter 2012 Revenues

Read more

Jan 02, 2013

Probuphine® Receives FDA Priority Review Designation

Read more

Dec 17, 2012

Titan Licenses Exclusive Probuphine® Commercialization Rights in U.S. & Canada

Read more

Dec 13, 2012

Tokai Pharmaceuticals Doses First Patient in a Phase 2 Study of Galeterone

Read more

Nov 20, 2012

HeartWare Receives FDA Approval for HeartWare Ventricular Assist System

Read more

Nov 09, 2012

HeartWare Reports Third Quarter 2012 Results

Read more

Aug 07, 2012

HeartWare Reports Second Quarter 2012 Results

Read more

Aug 02, 2012

HeartWare Completes Acquisition Of World Heart Corporation

Read more

Jun 12, 2012

Tokai Pharmaceuticals’ Galeterone Receives Fast Track Designation From the FDA

Read more

Apr 25, 2012

FDA Advisory Committee Votes in Favor of HeartWare® Ventricular Assist System

Read more

Apr 02, 2012

Positive Phase 1 data presented

Read more

Mar 29, 2012

HeartWare International Expands Intellectual Property and Technology Portfolio

Read more

Mar 14, 2012

10 Top Next-Gen Biotech Platforms

Read more

Feb 16, 2012

HeartWare International Reports Fourth Quarter 2011 Revenues of $23.1 Million

Read more

Nov 17, 2011

Aileron expands stapled peptide drug collaboration with Roche

Read more

Sep 20, 2011

Tokai Pharmaceuticals Raises $23 Million in Funding

Read more

Sep 20, 2011

Tokai Snaps Up $23M From Novartis and Apple Tree

Read more

Sep 20, 2011

Tokai lands new CEO, $23M venture round for PhIIb cancer study

Read more

Jun 16, 2011

FDA Grants Accelerated Approval of ISTODAX(R)

Read more

May 05, 2011

HeartWare International Reports First Quarter 2011 Revenues of $18.0 Million

Read more

Apr 15, 2011

HeartWare Reports Additional Data from Bridge-to-Transplant Clinical Trial

Read more

Mar 24, 2011

HeartWare International Receives Approval From the TGA in Australia

Read more

Feb 28, 2011

FDA Grants Priority Review For ISTODAX(R) sNDA

Read more

Feb 24, 2011

HeartWare International Reports Fourth Quarter 2010 Revenues of $20.9 Million

Read more

Jan 24, 2011

HeartWare Receives Third Patient Allotment From FDA

Read more

Dec 28, 2010

HeartWare Files PMA Application for FDA Approval

Read more

Dec 15, 2010

HeartWare Announces Completion of Concurrent Public Offerings

Read more

Dec 10, 2010

HeartWare Announces Pricing of Concurrent Public Offerings

Read more

Dec 09, 2010

HeartWare International, Inc. Announces Concurrent Public Offerings

Read more

Dec 05, 2010

New Clinical Data Evaluating ISTODAX(R) in Pivotal Open-Label Phase II Study

Read more

Nov 14, 2010

HeartWare 5-Ounce Pump Extends Lives in Heart Failure Patients

Read more

Nov 14, 2010

HeartWare Achieves Primary Endpoint

Read more

Aug 24, 2010

Roche Backs New Method for Drug Delivery to Cells

Read more

Aug 24, 2010

Roche Enters $1.1B Deal With Aileron To Produce New Drugs

Read more

Aug 01, 2010

Stapled Peptides on the cover of the August issue of Nature Chemical Biology

Read more

Jun 24, 2010

HeartWare Announces Board Succession

Read more

Jun 14, 2010

HeartWare Receives Conditional FDA Approval

Read more

Apr 23, 2010

HeartWare Data From First 100 Patients

Read more

Apr 07, 2010

HeartWare Receives FDA Approval of Continued Access Protocol

Read more

Feb 22, 2010

HeartWare Announces Early Conclusion of Enrollment

Read more

Feb 02, 2010

HeartWare Announces Completion of Public Offering of Common Stock

Read more

Jan 26, 2010

HeartWare Announces Commencement of Public Offering of Common Stock

Read more

Dec 07, 2009

Celgene to Acquire Gloucester Pharmaceuticals

Read more

Nov 27, 2009

Tokai eyes novel weapon to battle prostate cancer

Read more

Nov 11, 2009

Aileron Therapeutics Collaborators Publish In Vivo Research in Nature

Read more

Nov 05, 2009

FDA Approves Gloucester's ISTODAX® for Cutaneous T-cell Lymphoma

Read more

Oct 10, 2009

Tokai Pharmaceuticals Initiates ARMOR Program for TOK-001

Read more

Sep 02, 2009

FDA Advisory Committee Recommends Gloucester's Romidepsin for Approval

Read more

Aug 25, 2009

Gloucester raises $29 million

Read more

Aug 21, 2009

HeartWare International Surpasses 50 Implants In The US

Read more

Aug 17, 2009

HeartWare International, Inc. Closes US$60 Million Financing

Read more

Jun 08, 2009

Aileron Therapeutics Closes $40M Financing To Advance Stapled Peptide Platform

Read more

Jun 01, 2009

“Emerging Drug Developer” Tokai Pharmaceuticals

Read more

Oct 22, 2008

Aileron Advances First Stapled Peptide Drug Candidate

Read more